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Inhibitory Effects of Eucalyptus and Banaba Leaf Extracts on Nonalcoholic Steatohepatitis Induced by a High-FructoseHigh-Glucose Diet in Rats
Joint Authors
Takahashi, Yoshihisa
Sugimoto, Keiichiro
Soejima, Yurie
Kumagai, Arisa
Koeda, Tatsuki
Shojo, Aiko
Nakagawa, Kazuya
Harada, Naoki
Yamaji, Ryoichi
Inui, Hiroshi
Yamanouchi, Toshikazu
Fukusato, Toshio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nonalcoholic steatohepatitis (NASH) is a liver disease associated with metabolic syndrome.
The aim of this work was to examine whether eucalyptus (Eucalyptus globulus) leaf extract (ELE) and banaba (Lagerstroemia speciosa L.) leaf extract (BLE) inhibited NASH induced by excessive ingestion of fructose in rats.
Wistar rats were divided into four groups according to four distinct diets: starch diet (ST), high-fructose/high-glucose diet (FG), FG diet supplemented with ELE, or FG diet supplemented with BLE.
All rats were killed after 5 weeks of treatment.
Serum alanine aminotransferase and total cholesterol levels were significantly lower in the BLE group than in the FG group.
Liver histopathology, including steatosis, lipogranulomas, and perisinusoidal fibrosis, was significantly attenuated in the ELE and BLE groups compared with the FG group.
Levels of 2-thiobarbituric acid reactive substances (TBARS), which reflect oxidative injury to the liver, were significantly suppressed by ELE and BLE.
Western blotting analysis indicated that interleukin-6 expression levels were significantly lower in the ELE and BLE groups than in the FG group.
These results suggest that ELE and BLE reduced lipogenesis, oxidative stress, and inflammatory cytokine expression and thus inhibited NASH induced by excessive ingestion of fructose in rats.
American Psychological Association (APA)
Takahashi, Yoshihisa& Sugimoto, Keiichiro& Soejima, Yurie& Kumagai, Arisa& Koeda, Tatsuki& Shojo, Aiko…[et al.]. 2015. Inhibitory Effects of Eucalyptus and Banaba Leaf Extracts on Nonalcoholic Steatohepatitis Induced by a High-FructoseHigh-Glucose Diet in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054947
Modern Language Association (MLA)
Takahashi, Yoshihisa…[et al.]. Inhibitory Effects of Eucalyptus and Banaba Leaf Extracts on Nonalcoholic Steatohepatitis Induced by a High-FructoseHigh-Glucose Diet in Rats. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054947
American Medical Association (AMA)
Takahashi, Yoshihisa& Sugimoto, Keiichiro& Soejima, Yurie& Kumagai, Arisa& Koeda, Tatsuki& Shojo, Aiko…[et al.]. Inhibitory Effects of Eucalyptus and Banaba Leaf Extracts on Nonalcoholic Steatohepatitis Induced by a High-FructoseHigh-Glucose Diet in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054947