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Vitamin K1 Exerts Antiproliferative Effects and Induces Apoptosis in Three Differently Graded Human Colon Cancer Cell Lines
Joint Authors
Russo, Francesco
Orlando, Antonella
Linsalata, Michele
Tutino, Valeria
D'Attoma, Benedetta
Notarnicola, Maria
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Vitamin K1 has been demonstrated as having anticancer potentiality mainly in liver cancer cells.
Beyond the reported mechanisms of cancer inhibition (cell cycle arrest and induction of apoptosis), a possible control by vitamin K1 on molecules affecting cell growth could be hypothesized.
In the literature, few (if any) data are available on its antitumor effects on colon cancer cells.
Therefore, the aims of the study were to investigate in three differently graded human colon cancer cell lines (Caco-2, HT-29, and SW480) the effects of increasing concentrations of vitamin K1 (from 10 μM to 200 μM) administered up to 72 h on (1) cell proliferation, (2) apoptosis with the possible involvement of the MAPK pathway, and (3) polyamine biosynthesis.
Vitamin K1 treatment caused a significant antiproliferative effect and induced apoptosis in all the cell lines, with the involvement of the MAPK pathway.
A concomitant and significant decrease in the polyamine biosynthesis occurred.
This is the first study demonstrating a significant polyamine decrease in addition to the antiproliferative and proapoptotic effects following vitamin K1 administration to colon cancer cell lines.
Therapeutically, combinations of vitamin K1 with polyamine inhibitors and/or analogues may represent a suitable option for chemoprevention and/or treatment in future strategies for colorectal cancer management.
American Psychological Association (APA)
Orlando, Antonella& Linsalata, Michele& Tutino, Valeria& D'Attoma, Benedetta& Notarnicola, Maria& Russo, Francesco. 2015. Vitamin K1 Exerts Antiproliferative Effects and Induces Apoptosis in Three Differently Graded Human Colon Cancer Cell Lines. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1054948
Modern Language Association (MLA)
Orlando, Antonella…[et al.]. Vitamin K1 Exerts Antiproliferative Effects and Induces Apoptosis in Three Differently Graded Human Colon Cancer Cell Lines. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1054948
American Medical Association (AMA)
Orlando, Antonella& Linsalata, Michele& Tutino, Valeria& D'Attoma, Benedetta& Notarnicola, Maria& Russo, Francesco. Vitamin K1 Exerts Antiproliferative Effects and Induces Apoptosis in Three Differently Graded Human Colon Cancer Cell Lines. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1054948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054948