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Clearance Rate and BP-ANN Model in Paraquat Poisoned Patients Treated with Hemoperfusion
Joint Authors
Hu, Lufeng
Hong, Guangliang
Zhang, Xiuhua
Lu, Zhongqiu
Lin, Guanyang
Ma, Jianshe
Wang, Xianqin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In order to investigate the effect of hemoperfusion (HP) on the clearance rate of paraquat (PQ) and develop a clearance model, 41 PQ-poisoned patients who acquired acute PQ intoxication received HP treatment.
PQ concentrations were determined by high performance liquid chromatography (HPLC).
According to initial PQ concentration, study subjects were divided into two groups: Low-PQ group (0.05–1.0 μg/mL) and High-PQ group (1.0–10 μg/mL).
After initial HP treatment, PQ concentrations decreased in both groups.
However, in the High-PQ group, PQ levels remained in excess of 0.05 μg/mL and increased when the second HP treatment was initiated.
Based on the PQ concentrations before and after HP treatment, the mean clearance rate of PQ calculated was 73 ± 15%.
We also established a backpropagation artificial neural network (BP-ANN) model, which set PQ concentrations before HP treatment as input data and after HP treatment as output data.
When it is used to predict PQ concentration after HP treatment, high prediction accuracy (R=0.9977) can be obtained in this model.
In conclusion, HP is an effective way to clear PQ from the blood, and the PQ concentration after HP treatment can be predicted by BP-ANN model.
American Psychological Association (APA)
Hu, Lufeng& Hong, Guangliang& Ma, Jianshe& Wang, Xianqin& Lin, Guanyang& Zhang, Xiuhua…[et al.]. 2015. Clearance Rate and BP-ANN Model in Paraquat Poisoned Patients Treated with Hemoperfusion. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054952
Modern Language Association (MLA)
Hu, Lufeng…[et al.]. Clearance Rate and BP-ANN Model in Paraquat Poisoned Patients Treated with Hemoperfusion. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054952
American Medical Association (AMA)
Hu, Lufeng& Hong, Guangliang& Ma, Jianshe& Wang, Xianqin& Lin, Guanyang& Zhang, Xiuhua…[et al.]. Clearance Rate and BP-ANN Model in Paraquat Poisoned Patients Treated with Hemoperfusion. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054952