Dynamic Contrast-Enhanced CT Characterization of Xp11.2 TranslocationTFE3 Gene Fusions versus Papillary Renal Cell Carcinomas
Joint Authors
He, Jian
Zhou, Kefeng
Zhu, Bin
Zhang, Gutian
Li, Xiaogong
Guo, Hongqian
Gan, Weidong
Zhou, Zhengyang
Liu, Tian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To compare the differences of CT characteristics between renal cell carcinomas (RCCs) associated with Xp11.2 translocation/TFE3 gene fusions (Xp11.2 RCCs) and papillary cell renal cell carcinomas (PRCCs).
Methods.
CT images and clinical records of 64 patients (25 Xp11.2 RCCs, 15 type 1 and 24 type 2 PRCCs) were analyzed and compared retrospectively.
Results.
Xp11.2 RCC more frequently affected young (30.7±8.7 years) women (16/25, 64%) with gross hematuria (12/25, 48%), while PRCC more frequently involved middle-aged (54.8±11.1 years) men (28/39, 71.8%) asymptomatically.
Xp11.2 RCC tended to be heterogeneous density with some showing circular calcification.
Lesion sizes of Xp11.2 RCC (5.4±2.2 cm) and type 2 PRCC (5.7±2.5 cm) were significantly larger than that of type 1 PRCC (3.8±1.8 cm).
Xp11.2 RCC contained more cystic components (22/25, 88%) than type 1 PRCC (all solid) and type 2 PRCC (9/24, 36.0%).
Type 1 PRCC (13/15, 86.7%) and Xp11.2 RCC (21/25, 84.0%) showed more clear boundary than type 2 PRCC (12/24, 50.0%).
Conclusion.
CT features including diameter, boundary, attenuation, nature, and circular calcification of the tumor, combined with demographic information and symptoms, may be useful to differentiate Xp11.2 RCC from different subtypes of PRCC.
American Psychological Association (APA)
He, Jian& Zhou, Kefeng& Zhu, Bin& Zhang, Gutian& Li, Xiaogong& Guo, Hongqian…[et al.]. 2015. Dynamic Contrast-Enhanced CT Characterization of Xp11.2 TranslocationTFE3 Gene Fusions versus Papillary Renal Cell Carcinomas. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054957
Modern Language Association (MLA)
He, Jian…[et al.]. Dynamic Contrast-Enhanced CT Characterization of Xp11.2 TranslocationTFE3 Gene Fusions versus Papillary Renal Cell Carcinomas. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054957
American Medical Association (AMA)
He, Jian& Zhou, Kefeng& Zhu, Bin& Zhang, Gutian& Li, Xiaogong& Guo, Hongqian…[et al.]. Dynamic Contrast-Enhanced CT Characterization of Xp11.2 TranslocationTFE3 Gene Fusions versus Papillary Renal Cell Carcinomas. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054957