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Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in dbdb Mice
Joint Authors
Seo, Jung-Woo
Kim, Yang Gyun
Lee, Sang Ho
Lee, Arah
Kim, Dong-Jin
Jeong, Kyung-Hwan
Lee, Kyung Hye
Hwang, Seung Joon
Woo, Jong Shin
Lim, Sung Jig
Kim, Weon
Moon, Ju-Young
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chronic low-grade inflammation is an important factor in the pathogenesis of diabetic complication.
Mycophenolate mofetil (MMF) has an anti-inflammatory effect, inhibiting lymphocyte proliferation.
Previous studies showed attenuation of diabetic nephropathy with MMF, but the underlying mechanisms were unclear.
This study aimed to identify the effect of MMF on diabetic nephropathy and investigate its action mechanisms in type 2 diabetic mice model.
Eight-week-old db/db and control mice (db/m mice) received vehicle or MMF at a dose of 30 mg/kg/day for 12 weeks.
MMF-treated diabetic mice showed decreased albuminuria, attenuated mesangial expansion, and profibrotic mRNA expressions despite the high glucose level.
The number of infiltrated CD4+ and CD8+ T cells in the kidney was significantly decreased in MMF-treated db/db mice and it resulted in attenuating elevated intrarenal TNF-α and IL-17.
The renal chemokines expression and macrophages infiltration were also attenuated by MMF treatment.
The decreased expression of glomerular nephrin and WT1 was recovered with MMF treatment.
MMF prevented the progression of diabetic nephropathy in db/db mice independent of glycemic control.
These results suggest that the effects of MMF in diabetic nephropathy are mediated by CD4+ T cell regulation and related cytokines.
American Psychological Association (APA)
Seo, Jung-Woo& Kim, Yang Gyun& Lee, Sang Ho& Lee, Arah& Kim, Dong-Jin& Jeong, Kyung-Hwan…[et al.]. 2015. Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in dbdb Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054960
Modern Language Association (MLA)
Seo, Jung-Woo…[et al.]. Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in dbdb Mice. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054960
American Medical Association (AMA)
Seo, Jung-Woo& Kim, Yang Gyun& Lee, Sang Ho& Lee, Arah& Kim, Dong-Jin& Jeong, Kyung-Hwan…[et al.]. Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in dbdb Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054960