Gold Nanoparticles Promote Oxidant-Mediated Activation of NF-κB and 53BP1 Recruitment-Based Adaptive Response in Human Astrocytes
Joint Authors
Mytych, Jennifer
Lewinska, Anna
Zebrowski, Jacek
Wnuk, Maciej
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nanogold-based materials are promising candidate tools for nanobased medicine.
Nevertheless, no conclusive information on their cytotoxicity is available.
In the present study, we investigated the effects of gold nanoparticles (AuNPs) on human astrocytes in vitro.
Nanogold treatment in a wide range of concentrations did not result in cytotoxicity.
In contrast, nanogold provoked changes in the astrocyte cell cycle and induced senescence-associated β-galactosidase activity.
AuNPs promoted oxidative stress and caused activation of NF-κB pathway.
After nanogold treatment, an inverse correlation between the formation of 53BP1 foci and micronuclei generation was observed.
The robust 53BP1 recruitment resulted in reduced micronuclei production.
Thus, nanogold treatment stimulated an adaptive response in a human astrocyte cell.
American Psychological Association (APA)
Mytych, Jennifer& Lewinska, Anna& Zebrowski, Jacek& Wnuk, Maciej. 2015. Gold Nanoparticles Promote Oxidant-Mediated Activation of NF-κB and 53BP1 Recruitment-Based Adaptive Response in Human Astrocytes. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054974
Modern Language Association (MLA)
Mytych, Jennifer…[et al.]. Gold Nanoparticles Promote Oxidant-Mediated Activation of NF-κB and 53BP1 Recruitment-Based Adaptive Response in Human Astrocytes. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054974
American Medical Association (AMA)
Mytych, Jennifer& Lewinska, Anna& Zebrowski, Jacek& Wnuk, Maciej. Gold Nanoparticles Promote Oxidant-Mediated Activation of NF-κB and 53BP1 Recruitment-Based Adaptive Response in Human Astrocytes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054974