Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines
Joint Authors
Hassan, Rosline
Sulaiman, Siti Amrah
Nik Man, Nik Muhd Khuzaimi
Ang, Cheng Yong
Abdullah, Abu Dzarr
Mohd Radzi, Muhammad Amiro Rasheeq
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Complementary medicine using natural product as antitumor is on the rise.
Much research has been performed on Tualang Honey and it was shown to have therapeutic potential in wound healing, and antimicrobial activity and be antiproliferative against several cancer models such as human osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231), and cervical (HeLa) cancer cell lines.
To date, there was limited study on antileukemic properties of Tualang (Koompassia excelsa) Honey.
The aim of this study was to evaluate the antileukemic effect of Tualang Honey on acute and chronic leukemia cell lines.
Leukemia cell lines (K562 and MV4-11) and human mononuclear cell isolated from peripheral blood were grown in RPM1 1640 culture medium.
The cells were incubated with increasing concentrations of Tualang Honey.
After incubation, the evaluation of viability and apoptosis was performed.
The morphological changes of leukemia cells were the presence of cytoplasmic blebs followed by apoptotic bodies and round shape of cells.
IC50 against K562 and MV4-11 was determined.
Tualang Honey gave 53.9% and 50.6% apoptosis activity on K562 and MV4-11, respectively, while on human mononuclear cell it was 37.4%.
Tualang Honey has the apoptosis-inducing ability for acute and chronic myeloid leukemia (K562 and MV4-11) cell lines.
American Psychological Association (APA)
Nik Man, Nik Muhd Khuzaimi& Hassan, Rosline& Ang, Cheng Yong& Abdullah, Abu Dzarr& Mohd Radzi, Muhammad Amiro Rasheeq& Sulaiman, Siti Amrah. 2015. Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054986
Modern Language Association (MLA)
Nik Man, Nik Muhd Khuzaimi…[et al.]. Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054986
American Medical Association (AMA)
Nik Man, Nik Muhd Khuzaimi& Hassan, Rosline& Ang, Cheng Yong& Abdullah, Abu Dzarr& Mohd Radzi, Muhammad Amiro Rasheeq& Sulaiman, Siti Amrah. Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054986