Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer
Joint Authors
Chu, Pen-Yuan
Chen, Ming-Huang
Yang, Chao-Chun
Chang, Peter Mu-Hsin
Wang, Ling-Wei
Lu, Hsueh-Ju
Yang, Muh-Hwa
Tai, Shyh-Kuan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Triweekly cisplatin-based postoperative concurrent chemoradiotherapy (CCRT) has high intolerance and toxicities in locally advanced head and neck cancer (LAHNC).
We evaluated the effect of a modified weekly cisplatin-based chemotherapy in postoperative CCRT.
Methods.
A total of 117 patients with LAHNC were enrolled between December 2007 and December 2012.
Survival, compliance/adverse events, and independent prognostic factors were analyzed.
Results.
Median follow-up time was 30.0 (3.1–73.0) months.
Most patients completed the entire course of postoperative CCRT (radiotherapy ≥ 60 Gy, 94.9%; ≥6 times weekly chemotherapy, 75.2%).
Only 17.1% patients required hospital admission.
The most common adverse effect was grade 3/4 mucositis (28.2%).
No patient died due to protocol-related adverse effects.
Multivariate analysis revealed the following independent prognostic factors: oropharyngeal cancer, extracapsular spread, and total radiation dose.
Two-year progression-free survival and overall survival rates were 70.9% and 79.5%, respectively.
Conclusion.
Modified weekly cisplatin-based chemotherapy is an acceptable regimen in postoperative CCRT for LAHNC.
American Psychological Association (APA)
Lu, Hsueh-Ju& Yang, Chao-Chun& Wang, Ling-Wei& Chu, Pen-Yuan& Tai, Shyh-Kuan& Chen, Ming-Huang…[et al.]. 2014. Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054987
Modern Language Association (MLA)
Lu, Hsueh-Ju…[et al.]. Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054987
American Medical Association (AMA)
Lu, Hsueh-Ju& Yang, Chao-Chun& Wang, Ling-Wei& Chu, Pen-Yuan& Tai, Shyh-Kuan& Chen, Ming-Huang…[et al.]. Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer. BioMed Research International. 2014. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054987