In Vitro and In Vivo Evaluation of Vancomycin-Loaded PMMA Cement in Combination with Ultrasound and Microbubbles-Mediated Ultrasound
Joint Authors
Hu, Bin
Lin, Tiao
Ying, Zhi-Min
Shi, Ming-Min
Zhou, Chen-He
Wang, Wei
Yan, Shi-Gui
Cai, Xun-Zi
Shi, Zhong-Li
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ultrasound (US) has been used to increase elution of antibiotic from an antibiotic-loaded poly(methyl methacrylate) (PMMA) bone cement (ALBC).
We aimed to further investigate whether microbubbles-mediated US (US + MB) facilitate elution of vancomycin (VAN) from cylindrical specimens and enhance the activity of the eluted antibiotic against Staphylococcus aureus (S.
aureus) in vitro.
The study groups comprised cylindrical bone cement fabricated with VAN (VAN), ALBC using US (VAN + US), and ALBC using MB-mediated US (VAN + US + MB).
We also carried out an in vivo study involving the activity of VAN from cylindrical cement implanted in tibiae of New Zealand white rabbits inoculated with S.
aureus.
We found that (1) in vitro, elution from VAN + US + MB cylinders was significantly higher than from either the VAN or VAN + US specimens; (2) the activity of the eluted VAN from the VAN + US + MB cylinders against planktonic S.
aureus was significantly higher than from either the control or VAN or VAN + US specimens; and (3) in the rabbits, the activity of the eluted VAN from the VAN + US + MB cylinders against S.
aureus was significantly higher than from either the control or VAN or VAN + US specimens.
The present results suggest that VAN-loaded PMMA cement irradiated with MB-mediated US may have a role in controlling prosthetic joint infection.
American Psychological Association (APA)
Lin, Tiao& Cai, Xun-Zi& Shi, Ming-Min& Ying, Zhi-Min& Hu, Bin& Zhou, Chen-He…[et al.]. 2015. In Vitro and In Vivo Evaluation of Vancomycin-Loaded PMMA Cement in Combination with Ultrasound and Microbubbles-Mediated Ultrasound. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054997
Modern Language Association (MLA)
Lin, Tiao…[et al.]. In Vitro and In Vivo Evaluation of Vancomycin-Loaded PMMA Cement in Combination with Ultrasound and Microbubbles-Mediated Ultrasound. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054997
American Medical Association (AMA)
Lin, Tiao& Cai, Xun-Zi& Shi, Ming-Min& Ying, Zhi-Min& Hu, Bin& Zhou, Chen-He…[et al.]. In Vitro and In Vivo Evaluation of Vancomycin-Loaded PMMA Cement in Combination with Ultrasound and Microbubbles-Mediated Ultrasound. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054997