A Systematic Analysis of Candidate Genes Associated with Nicotine Addiction
Joint Authors
Liu, Meng
Li, Xia
Fan, Rui
Liu, Xinhua
Wang, Ju
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nicotine, as the major psychoactive component of tobacco, has broad physiological effects within the central nervous system, but our understanding of the molecular mechanism underlying its neuronal effects remains incomplete.
In this study, we performed a systematic analysis on a set of nicotine addiction-related genes to explore their characteristics at network levels.
We found that NAGenes tended to have a more moderate degree and weaker clustering coefficient and to be less central in the network compared to alcohol addiction-related genes or cancer genes.
Further, clustering of these genes resulted in six clusters with themes in synaptic transmission, signal transduction, metabolic process, and apoptosis, which provided an intuitional view on the major molecular functions of the genes.
Moreover, functional enrichment analysis revealed that neurodevelopment, neurotransmission activity, and metabolism related biological processes were involved in nicotine addiction.
In summary, by analyzing the overall characteristics of the nicotine addiction related genes, this study provided valuable information for understanding the molecular mechanisms underlying nicotine addiction.
American Psychological Association (APA)
Liu, Meng& Li, Xia& Fan, Rui& Liu, Xinhua& Wang, Ju. 2015. A Systematic Analysis of Candidate Genes Associated with Nicotine Addiction. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055004
Modern Language Association (MLA)
Liu, Meng…[et al.]. A Systematic Analysis of Candidate Genes Associated with Nicotine Addiction. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055004
American Medical Association (AMA)
Liu, Meng& Li, Xia& Fan, Rui& Liu, Xinhua& Wang, Ju. A Systematic Analysis of Candidate Genes Associated with Nicotine Addiction. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055004