Th17 Cell Plasticity and Functions in Cancer Immunity
Joint Authors
Guéry, Leslie
Hugues, Stéphanie
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Th17 cells represent a particular subset of T helper lymphocytes characterized by high production of IL-17 and other inflammatory cytokines.
Th17 cells participate in antimicrobial immunity at mucosal and epithelial barriers and particularly fight against extracellular bacteria and fungi.
While a role for Th17 cells in promoting inflammation and autoimmune disorders has been extensively and elegantly demonstrated, it is still controversial whether and how Th17 cells influence tumor immunity.
Although Th17 cells specifically accumulate in many different types of tumors compared to healthy tissues, the outcome might however differ from a tumor type to another.
Th17 cells were consequently associated with both good and bad prognoses.
The high plasticity of those cells toward cells exhibiting either anti-inflammatory or in contrast pathogenic functions might contribute to Th17 versatile functions in the tumor context.
On one hand, Th17 cells promote tumor growth by inducing angiogenesis (via IL-17) and by exerting themselves immunosuppressive functions.
On the other hand, Th17 cells drive antitumor immune responses by recruiting immune cells into tumors, activating effector CD8+ T cells, or even directly by converting toward Th1 phenotype and producing IFN-γ.
In this review, we are discussing the impact of the tumor microenvironment on Th17 cell plasticity and function and its implications in cancer immunity.
American Psychological Association (APA)
Guéry, Leslie& Hugues, Stéphanie. 2015. Th17 Cell Plasticity and Functions in Cancer Immunity. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055009
Modern Language Association (MLA)
Guéry, Leslie& Hugues, Stéphanie. Th17 Cell Plasticity and Functions in Cancer Immunity. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055009
American Medical Association (AMA)
Guéry, Leslie& Hugues, Stéphanie. Th17 Cell Plasticity and Functions in Cancer Immunity. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055009