Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling
Joint Authors
Wei, Meng
Li, Shugang
Ding, Yusong
Niu, Qiang
Xu, Shangzhi
Pang, Lijuan
Ma, Rulin
Jing, Mingxia
Feng, Gangling
Tang, Jing Xia
Zhang, Qian
Ma, Xiaomei
Yan, Yizhong
Zhang, Jingyu
Wang, Hai Xia
Li, Feng
Guo, Shuxia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Arsenic produces liver disease through the oxidative stress.
While lutein can alleviate cytotoxic and oxidative injury, nuclear factor erythroid 2-related factor 2 (Nrf2) pathway plays a critical role in defending oxidative species.
However, the mechanisms by which lutein protects the liver against the effect of arsenic are not known.
Therefore, this study aims to investigate the mechanisms involved in the action of lutein using mice model in which hepatotoxicity was induced by arsenic.
We found that mice treatment with lutein could reverse changes in morphological and liver indexes and result in a significant improvement in hepatic function comparing with arsenic trioxide group.
Lutein treatment improved the activities of antioxidant enzymes and attenuated increasing of ROS and MDA induced by arsenic trioxide.
Lutein could increase the mRNA and protein expression of Nrf2 signaling related genes (Nrf2, Nqo1, Ho-1, and Gst).
These findings provide additional evidence that lutein may be useful for reducing reproductive injury associated with oxidative stress by the activation of Nrf2 signaling.
Our findings suggest a possible mechanism of antioxidant lutein in preventing the hepatotoxicity, which implicate that a dietary lutein may be a potential treatment for liver diseases, especially for arsenicosis therapy.
American Psychological Association (APA)
Li, Shugang& Ding, Yusong& Niu, Qiang& Xu, Shangzhi& Pang, Lijuan& Ma, Rulin…[et al.]. 2015. Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055016
Modern Language Association (MLA)
Li, Shugang…[et al.]. Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055016
American Medical Association (AMA)
Li, Shugang& Ding, Yusong& Niu, Qiang& Xu, Shangzhi& Pang, Lijuan& Ma, Rulin…[et al.]. Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055016