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Anti-EGFR Antibody Reduces Lung Nodules by Inhibition of EGFR-Pathway in a Model of Lymphangioleiomyomatosis
Joint Authors
Lesma, Elena
Chiaramonte, Eloisa
Ancona, Silvia
Orpianesi, Emanuela
Di Giulio, Anna Maria
Gorio, Alfredo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
EGFR belongs to the HER/ErbB family of tyrosine kinase receptors and its activation in cancer cells has been linked with increased proliferation, angiogenesis, and metastasis.
Lymphangioleiomyomatosis (LAM) is a rare, low-grade neoplasm that occurs sporadically or in association with tuberous sclerosis complex (TSC), a genetic, multisystem disorder characterized by hamartomas in several organs.
From chylous of a LAM/TSC patient, we previously isolated smooth muscle-like LAM/TSC cells whose proliferation depends on EGF and monoclonal anti-EGFR antibodies reduced proliferation and caused cell death.
We demonstrated that the dependency from EGF was caused by the absence of tuberin.
To study the role of EGFR pathway in vivo, we developed a mouse model by administration of LAM/TSC cells to female nude mice.
LAM/TSC cells caused pulmonary airspace enlargement and, after 30 weeks, nodule formation which express EGFR.
Anti-EGFR antibody decreased the number and dimension of lung nodules likely for the inhibition of Erk and S6 signaling, reversed the pulmonary alterations, and reduced lymphatic and blood vessels.
Moreover, in pulmonary nodules anti-EGFR antibody reduced the positivity to estrogen and progesterone receptors which enhance survival of LAM cells and Snail expression.
These results suggest that the inhibition of EGFR signalling has a potential in treatment of LAM/TSC lung alterations.
American Psychological Association (APA)
Lesma, Elena& Chiaramonte, Eloisa& Ancona, Silvia& Orpianesi, Emanuela& Di Giulio, Anna Maria& Gorio, Alfredo. 2015. Anti-EGFR Antibody Reduces Lung Nodules by Inhibition of EGFR-Pathway in a Model of Lymphangioleiomyomatosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055017
Modern Language Association (MLA)
Lesma, Elena…[et al.]. Anti-EGFR Antibody Reduces Lung Nodules by Inhibition of EGFR-Pathway in a Model of Lymphangioleiomyomatosis. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1055017
American Medical Association (AMA)
Lesma, Elena& Chiaramonte, Eloisa& Ancona, Silvia& Orpianesi, Emanuela& Di Giulio, Anna Maria& Gorio, Alfredo. Anti-EGFR Antibody Reduces Lung Nodules by Inhibition of EGFR-Pathway in a Model of Lymphangioleiomyomatosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055017