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Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility
Joint Authors
Sugimura, Haruhiko
Nishizawa, Daisuke
Kasai, Shinya
Hasegawa, Junko
Sato, Naomi
Ikeda, Kazutaka
Tanioka, Fumihiko
Dobashi, Yoh
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To clarify the potential role of variability within and around the AKT1 gene in smoking behaviors, we performed a single-nucleotide polymorphism (SNP) analysis of the AKT1 gene in an elderly Japanese cohort.
Genotypes of the rs2498794 SNP, which is located in the fifth intron region of the AKT1 gene, were marginally but significantly associated with smoking duration in the total 999 samples of former and current smokers.
Interestingly, this SNP had a marginally significant association with individual cancer history (past and current), especially in groups with a shorter smoking duration (<44 years) and fewer cigarettes per day (≤20).
These data suggest that the rs2498794 polymorphism of the AKT1 gene is associated with a long smoking duration and may be involved in the predisposition to cancer when the smoking duration is short or the cigarettes per day is rate low.
American Psychological Association (APA)
Nishizawa, Daisuke& Kasai, Shinya& Hasegawa, Junko& Sato, Naomi& Tanioka, Fumihiko& Sugimura, Haruhiko…[et al.]. 2015. Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055024
Modern Language Association (MLA)
Nishizawa, Daisuke…[et al.]. Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055024
American Medical Association (AMA)
Nishizawa, Daisuke& Kasai, Shinya& Hasegawa, Junko& Sato, Naomi& Tanioka, Fumihiko& Sugimura, Haruhiko…[et al.]. Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055024