Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8
Joint Authors
Yao, Shaobo
Hu, Kongzhen
Tang, Ganghua
Gao, Siyuan
Tang, Caihua
Yao, Baoguo
Nie, Dahong
Sun, Ting
Jiang, Shende
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In this paper, a novel small-molecular apoptotic PET imaging probe, 18F-ML-8 with a malonate motif structure, is presented and discussed.
After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice.
The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay.
As a result, 18F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.
American Psychological Association (APA)
Yao, Shaobo& Hu, Kongzhen& Tang, Ganghua& Gao, Siyuan& Tang, Caihua& Yao, Baoguo…[et al.]. 2015. Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055027
Modern Language Association (MLA)
Yao, Shaobo…[et al.]. Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055027
American Medical Association (AMA)
Yao, Shaobo& Hu, Kongzhen& Tang, Ganghua& Gao, Siyuan& Tang, Caihua& Yao, Baoguo…[et al.]. Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055027
