The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease
Joint Authors
Lόpez Hoyos, Marcos
Arias-Loste, María Teresa
Crespo, Javier
Fábrega, Emilio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) has become a major health issue in western countries in parallel with the dramatic increase in the prevalence of obesity and all obesity related conditions, including respiratory diseases as obstructive sleep apnea-hypopnea syndrome (OSAHS).
Interestingly, the severity of the liver damage in obesity-related NAFLD has been associated with the concomitant presence of OSAHS.
In the presence of obesity, the proinflammatory state in these patients together with intermittent episodes of hypoxia, characteristic of OSAHS pathogenesis, may lead to an enhanced inflammatory response mediated by a positive feedback loop mechanism that implicates HIF-1 and NFκB.
Thus, the severity of liver involvement in obese NAFLD patients with a concomitant diagnosis of OSAHS could be explained.
In this review, we focus on the molecular mechanisms underlying the hepatic response to chronic intermittent hypoxia and its interaction with innate immunity in obesity-related NAFLD.
American Psychological Association (APA)
Arias-Loste, María Teresa& Fábrega, Emilio& Lόpez Hoyos, Marcos& Crespo, Javier. 2015. The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055047
Modern Language Association (MLA)
Arias-Loste, María Teresa…[et al.]. The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055047
American Medical Association (AMA)
Arias-Loste, María Teresa& Fábrega, Emilio& Lόpez Hoyos, Marcos& Crespo, Javier. The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055047