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The Role of Epigenetics in Arterial Calcification
Joint Authors
Wu, Shan-Shan
Lin, Xiao
Liao, Er-Yuan
Yuan, Ling-Qing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Arterial calcification is highly prevalent and correlated with cardiovascular mortality, especially in patients with ESRD or diabetes.
The pathogenesis of arterial calcification is multifactorial, with both genetic and environmental factors being implicated.
In recent years, several mechanisms contributing to arterial calcification have been proposed.
However, these can only explain a small proportion of the variability in arterial calcification, which is a major obstacle for its prevention and management.
Epigenetics has emerged as one of the most promising areas that may fill in some of the gaps in our current knowledge of the interaction between the environmental insults with gene regulation in the development of diseases.
Epigenetics refers to heritable and acquired changes in gene transcription that occur independently of the DNA sequence.
Well-known components of epigenetic regulation include DNA methylation, histone modifications, and microRNAs.
Epigenetics research in the regulation of arterial calcification has only recently been elucidated.
In this review, we will summarise recent progress in epigenetic pathways involved in arterial calcification and discuss potential therapeutic interventions based on epigenetic mechanisms.
American Psychological Association (APA)
Wu, Shan-Shan& Lin, Xiao& Yuan, Ling-Qing& Liao, Er-Yuan. 2015. The Role of Epigenetics in Arterial Calcification. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055057
Modern Language Association (MLA)
Wu, Shan-Shan…[et al.]. The Role of Epigenetics in Arterial Calcification. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055057
American Medical Association (AMA)
Wu, Shan-Shan& Lin, Xiao& Yuan, Ling-Qing& Liao, Er-Yuan. The Role of Epigenetics in Arterial Calcification. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055057