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In Vitro Behavior of Human Adipose Tissue-Derived Stem Cells on Poly(ε-caprolactone) Film for Bone Tissue Engineering Applications
Joint Authors
Romagnoli, Cecilia
Zonefrati, Roberto
Galli, Gianna
Puppi, Dario
Pirosa, Alessandro
Chiellini, Federica
Martelli, Francesco Saverio
Tanini, Annalisa
Brandi, Maria Luisa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Bone tissue engineering is an emerging field, representing one of the most exciting challenges for scientists and clinicians.
The possibility of combining mesenchymal stem cells and scaffolds to create engineered tissues has brought attention to a large variety of biomaterials in combination with osteoprogenitor cells able to promote and regenerate bone tissue.
Human adipose tissue is officially recognized as an easily accessible source of mesenchymal stem cells (AMSCs), a significant factor for use in tissue regenerative medicine.
In this study, we analyze the behavior of a clonal finite cell line derived from human adipose tissue seeded on poly(ε-caprolactone) (PCL) film, prepared by solvent casting.
PCL polymer is chosen for its good biocompatibility, biodegradability, and mechanical properties.
We observe that AMSCs are able to adhere to the biomaterial and remain viable for the entire experimental period.
Moreover, we show that the proliferation process and osteogenic activity of AMSCs are maintained on the biofilm, demonstrating that the selected biomaterial ensures cell colonization and the development of an extracellular mineralized matrix.
The results of this study highlight that AMSCs and PCL film can be used as a suitable model to support regeneration of new bone for future tissue engineering strategies.
American Psychological Association (APA)
Romagnoli, Cecilia& Zonefrati, Roberto& Galli, Gianna& Puppi, Dario& Pirosa, Alessandro& Chiellini, Federica…[et al.]. 2015. In Vitro Behavior of Human Adipose Tissue-Derived Stem Cells on Poly(ε-caprolactone) Film for Bone Tissue Engineering Applications. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055068
Modern Language Association (MLA)
Romagnoli, Cecilia…[et al.]. In Vitro Behavior of Human Adipose Tissue-Derived Stem Cells on Poly(ε-caprolactone) Film for Bone Tissue Engineering Applications. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055068
American Medical Association (AMA)
Romagnoli, Cecilia& Zonefrati, Roberto& Galli, Gianna& Puppi, Dario& Pirosa, Alessandro& Chiellini, Federica…[et al.]. In Vitro Behavior of Human Adipose Tissue-Derived Stem Cells on Poly(ε-caprolactone) Film for Bone Tissue Engineering Applications. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055068