CCAATEnhancer Binding Protein β in relation to ER Stress, Inflammation, and Metabolic Disturbances
Joint Authors
van der Krieken, Sophie E.
Popeijus, Herman E.
Mensink, Ronald P.
Plat, Jogchum
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The prevalence of the metabolic syndrome and underlying metabolic disturbances increase rapidly in developed countries.
Various molecular targets are currently under investigation to unravel the molecular mechanisms that cause these disturbances.
This is done in attempt to counter or prevent the negative health consequences of the metabolic disturbances.
Here, we reviewed the current knowledge on the role of C/EBP-β in these metabolic disturbances.
C/EBP-β deletion in mice resulted in downregulation of hepatic lipogenic genes and increased expression of β-oxidation genes in brown adipose tissue.
Furthermore, C/EBP-β is important in the differentiation and maturation of adipocytes and is increased during ER stress and proinflammatory conditions.
So far, studies were only conducted in animals and in cell systems.
The results found that C/EBP-β is an important transcription factor within the metabolic disturbances of the metabolic system.
Therefore, it is interesting to examine the potential role of C/EBP-β at molecular and physiological level in humans.
American Psychological Association (APA)
van der Krieken, Sophie E.& Popeijus, Herman E.& Mensink, Ronald P.& Plat, Jogchum. 2015. CCAATEnhancer Binding Protein β in relation to ER Stress, Inflammation, and Metabolic Disturbances. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055074
Modern Language Association (MLA)
van der Krieken, Sophie E.…[et al.]. CCAATEnhancer Binding Protein β in relation to ER Stress, Inflammation, and Metabolic Disturbances. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055074
American Medical Association (AMA)
van der Krieken, Sophie E.& Popeijus, Herman E.& Mensink, Ronald P.& Plat, Jogchum. CCAATEnhancer Binding Protein β in relation to ER Stress, Inflammation, and Metabolic Disturbances. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055074