Cellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum
Joint Authors
Zhao, Min
Qu, Hong
Chen, Xueying
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
T.
pallidum, the syphilis-causing pathogen, performs very differently in metabolism compared with other bacterial pathogens.
The desire for safe and effective vaccine of syphilis requests identification of important steps in T.
pallidum’s metabolism.
Here, we apply Flux Balance Analysis to represent the reactions quantitatively.
Thus, it is possible to cluster all reactions in T.
pallidum.
By calculating minimal cut sets and analyzing topological structure for the metabolic network of T.
pallidum, critical reactions are identified.
As a comparison, we also apply the analytical approaches to the metabolic network of H.
pylori to find coregulated drug targets and unique drug targets for different microorganisms.
Based on the clustering results, all reactions are further classified into various roles.
Therefore, the general picture of their metabolic network is obtained and two types of reactions, both of which are involved in nucleic acid metabolism, are found to be essential for T.
pallidum.
It is also discovered that both hubs of reactions and the isolated reactions in purine and pyrimidine metabolisms play important roles in T.
pallidum.
These reactions could be potential drug targets for treating syphilis.
American Psychological Association (APA)
Chen, Xueying& Zhao, Min& Qu, Hong. 2015. Cellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055096
Modern Language Association (MLA)
Chen, Xueying…[et al.]. Cellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055096
American Medical Association (AMA)
Chen, Xueying& Zhao, Min& Qu, Hong. Cellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055096