Development of In Vitro-In Vivo CorrelationRelationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus
Joint Authors
Dohnal, Jiri
Čulen, Martin
Tuszyński, Paweł K.
Polak, Sebastian
Jachowicz, Renata
Mendyk, Aleksander
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Different batches of atorvastatin, represented by two immediate release formulation designs, were studied using a novel dynamic dissolution apparatus, simulating stomach and small intestine.
A universal dissolution method was employed which simulated the physiology of human gastrointestinal tract, including the precise chyme transit behavior and biorelevant conditions.
The multicompartmental dissolution data allowed direct observation and qualitative discrimination of the differences resulting from highly pH dependent dissolution behavior of the tested batches.
Further evaluation of results was performed using IVIVC/IVIVR development.
While satisfactory correlation could not be achieved using a conventional deconvolution based-model, promising results were obtained through the use of a nonconventional approach exploiting the complex compartmental dissolution data.
American Psychological Association (APA)
Čulen, Martin& Tuszyński, Paweł K.& Polak, Sebastian& Jachowicz, Renata& Mendyk, Aleksander& Dohnal, Jiri. 2015. Development of In Vitro-In Vivo CorrelationRelationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055097
Modern Language Association (MLA)
Čulen, Martin…[et al.]. Development of In Vitro-In Vivo CorrelationRelationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055097
American Medical Association (AMA)
Čulen, Martin& Tuszyński, Paweł K.& Polak, Sebastian& Jachowicz, Renata& Mendyk, Aleksander& Dohnal, Jiri. Development of In Vitro-In Vivo CorrelationRelationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055097