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Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels
Joint Authors
Liu, Jun-Ling
Liu, Chunfang
Jing, Xiang-Hong
Xu, Ying
Chen, Shuping
Wang, Chao
Wan, Hongye
Sun, Danni
Xu, Tengfei
Yang, Yue
Qu, Yakun
Liu, Zhiqiang
Wang, Danhua
Lin, Na
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Wu-tou decoction (WTD) is a classic traditional Chinese medicine formula and has been used effectively to treat joint diseases clinically.
Previous reports indicated that WTD possesses anti-inflammatory activity; however, its actions on pain have not been clarified.
Here, we investigated the antinociceptive activity of WTD in CFA-induced mice, and its possible mechanism of the action associated with transient receptor potential (TRP) ion channels was also explored.
Our results showed that 1.58, 3.15, and 6.30 g/kg WTD significantly attenuated mechanical, cold, and heat hypersensitivities.
Moreover, WTD effectively inhibited spontaneous nociceptive responses to intraplantar injections of capsaicin and cinnamaldehyde, respectively.
WTD also effectively suppressed jumping and wet-dog-shake behaviors to intraperitoneal injection of icilin.
Additionally, WTD significantly reduced protein expression of TRPV1 and TRPA1 in dorsal root ganglia and skins of injured paw.
Collectively, our data demonstrate firstly that WTD exerts antinociceptive activity in inflammatory conditions by attenuating mechanical, cold, and heat hypersensitivities.
This antinociceptive effect may result in part from inhibiting the activities of TRPV1, TRPA1, and TRPM8, and the suppression of TRPV1 and TRPA1 protein by WTD was also highly effective.
These findings suggest that WTD might be an attractive and suitable therapeutic agent for the management of chronic inflammatory pain.
American Psychological Association (APA)
Wang, Chao& Liu, Chunfang& Wan, Hongye& Wang, Danhua& Sun, Danni& Xu, Tengfei…[et al.]. 2015. Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055099
Modern Language Association (MLA)
Wang, Chao…[et al.]. Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055099
American Medical Association (AMA)
Wang, Chao& Liu, Chunfang& Wan, Hongye& Wang, Danhua& Sun, Danni& Xu, Tengfei…[et al.]. Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055099