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Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes
Joint Authors
Toss, Angela
Tomasello, Chiara
Razzaboni, Elisabetta
Contu, Giannina
Grandi, Giovanni
Cagnacci, Angelo
Schilder, Russell J.
Cortesi, Laura
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
More than one-fifth of ovarian tumors have hereditary susceptibility and, in about 65–85% of these cases, the genetic abnormality is a germline mutation in BRCA genes.
Nevertheless, several other suppressor genes and oncogenes have been associated with hereditary ovarian cancers, including the mismatch repair (MMR) genes in Lynch syndrome, the tumor suppressor gene, TP53, in the Li-Fraumeni syndrome, and several other genes involved in the double-strand breaks repair system, such as CHEK2, RAD51, BRIP1, and PALB2.
The study of genetic discriminators and deregulated pathways involved in hereditary ovarian syndromes is relevant for the future development of molecular diagnostic strategies and targeted therapeutic approaches.
The recent development and implementation of next-generation sequencing technologies have provided the opportunity to simultaneously analyze multiple cancer susceptibility genes, reduce the delay and costs, and optimize the molecular diagnosis of hereditary tumors.
Particularly, the identification of mutations in ovarian cancer susceptibility genes in healthy women may result in a more personalized cancer risk management with tailored clinical and radiological surveillance, chemopreventive approaches, and/or prophylactic surgeries.
On the other hand, for ovarian cancer patients, the identification of mutations may provide potential targets for biologic agents and guide treatment decision-making.
American Psychological Association (APA)
Toss, Angela& Tomasello, Chiara& Razzaboni, Elisabetta& Contu, Giannina& Grandi, Giovanni& Cagnacci, Angelo…[et al.]. 2015. Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055111
Modern Language Association (MLA)
Toss, Angela…[et al.]. Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055111
American Medical Association (AMA)
Toss, Angela& Tomasello, Chiara& Razzaboni, Elisabetta& Contu, Giannina& Grandi, Giovanni& Cagnacci, Angelo…[et al.]. Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055111