Potential Peripartum Markers of Infectious-Inflammatory Complications in Spontaneous Preterm Birth
Joint Authors
Tambor, Vojtech
Vajrychova, Marie
Kacerovsky, Marian
Link, Marek
Domasinska, Petra
Lenco, Juraj
Menon, Ramkumar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Spontaneous preterm birth significantly contributes to the overall neonatal morbidity associated with preterm deliveries.
Nearly 50% of cases are associated with microbial invasion of the amniotic cavity followed by an inflammatory response.
Robust diagnostic tools for neonates jeopardized by infection and inflammation may thus decrease the overall neonatal morbidity substantially.
Amniotic fluid retrieved during labor retains fetal and pregnancy-related protein fingerprint and its sampling does not place any unwanted stress on women.
Using exploratory and targeted methods we analyzed proteomes of amniotic fluid sampled at the end of spontaneous preterm labor prior to delivery from women with and without infection and inflammation.
Exploratory data indicated several amniotic fluid proteins to be associated with infectious-inflammatory complications in spontaneous preterm birth.
LC-SRM analysis subsequently verified statistically significant changes in lipocalin-1 (P=0.047 and AUC = 0.67, P=0.046), glycodelin (P=0.013 and AUC = 0.73, P=0.013), and nicotinamide phosphoribosyltransferase (P=0.018 and AUC = 0.71, P=0.01).
American Psychological Association (APA)
Tambor, Vojtech& Vajrychova, Marie& Kacerovsky, Marian& Link, Marek& Domasinska, Petra& Menon, Ramkumar…[et al.]. 2015. Potential Peripartum Markers of Infectious-Inflammatory Complications in Spontaneous Preterm Birth. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055123
Modern Language Association (MLA)
Tambor, Vojtech…[et al.]. Potential Peripartum Markers of Infectious-Inflammatory Complications in Spontaneous Preterm Birth. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055123
American Medical Association (AMA)
Tambor, Vojtech& Vajrychova, Marie& Kacerovsky, Marian& Link, Marek& Domasinska, Petra& Menon, Ramkumar…[et al.]. Potential Peripartum Markers of Infectious-Inflammatory Complications in Spontaneous Preterm Birth. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055123