Altered Synchronizations among Neural Networks in Geriatric Depression
Joint Authors
Wang, Lihong
Chou, Ying-Hui
Potter, Guy G.
Steffens, David C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although major depression has been considered as a manifestation of discoordinated activity between affective and cognitive neural networks, only a few studies have examined the relationships among neural networks directly.
Because of the known disconnection theory, geriatric depression could be a useful model in studying the interactions among different networks.
In the present study, using independent component analysis to identify intrinsically connected neural networks, we investigated the alterations in synchronizations among neural networks in geriatric depression to better understand the underlying neural mechanisms.
Resting-state fMRI data was collected from thirty-two patients with geriatric depression and thirty-two age-matched never-depressed controls.
We compared the resting-state activities between the two groups in the default-mode, central executive, attention, salience, and affective networks as well as correlations among these networks.
The depression group showed stronger activity than the controls in an affective network, specifically within the orbitofrontal region.
However, unlike the never-depressed controls, geriatric depression group lacked synchronized/antisynchronized activity between the affective network and the other networks.
Those depressed patients with lower executive function has greater synchronization between the salience network with the executive and affective networks.
Our results demonstrate the effectiveness of the between-network analyses in examining neural models for geriatric depression.
American Psychological Association (APA)
Wang, Lihong& Chou, Ying-Hui& Potter, Guy G.& Steffens, David C.. 2015. Altered Synchronizations among Neural Networks in Geriatric Depression. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055125
Modern Language Association (MLA)
Wang, Lihong…[et al.]. Altered Synchronizations among Neural Networks in Geriatric Depression. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055125
American Medical Association (AMA)
Wang, Lihong& Chou, Ying-Hui& Potter, Guy G.& Steffens, David C.. Altered Synchronizations among Neural Networks in Geriatric Depression. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055125