Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients

Joint Authors

Salvi, Richard J.
Chen, Yu-Chen
Xia, Wenqing
Feng, Yuan
Li, Xiaowei
Zhang, Jian
Feng, Xu
Wang, Cong-Xiao
Cai, Yu
Wang, Jian
Teng, Gao-jun

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-02-19

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Purpose.

Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction.

To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), to examine the resting-state interhemispheric functional connectivity and its relationships with clinical characteristics in chronic tinnitus patients.

Materials and Methods.

Twenty-eight chronic tinnitus patients with normal hearing thresholds and 30 age-, sex-, education-, and hearing threshold-matched healthy controls were included in this study and underwent the resting-state fMRI scanning.

We computed the VMHC to analyze the interhemispheric functional coordination between homotopic points of the brain in both groups.

Results.

Compared to the controls, tinnitus patients showed significantly increased VMHC in the middle temporal gyrus, middle frontal gyrus, and superior occipital gyrus.

In tinnitus patients, a positive correlation was found between tinnitus duration and VMHC of the uncus.

Moreover, correlations between VMHC changes and tinnitus distress were observed in the transverse temporal gyrus, superior temporal pole, precentral gyrus, and calcarine cortex.

Conclusions.

These results show altered interhemispheric functional connectivity linked with specific tinnitus characteristics in chronic tinnitus patients, which may be implicated in the neuropathophysiology of tinnitus.

American Psychological Association (APA)

Chen, Yu-Chen& Xia, Wenqing& Feng, Yuan& Li, Xiaowei& Zhang, Jian& Feng, Xu…[et al.]. 2015. Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055134

Modern Language Association (MLA)

Chen, Yu-Chen…[et al.]. Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055134

American Medical Association (AMA)

Chen, Yu-Chen& Xia, Wenqing& Feng, Yuan& Li, Xiaowei& Zhang, Jian& Feng, Xu…[et al.]. Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055134

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1055134