Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients
Joint Authors
Salvi, Richard J.
Chen, Yu-Chen
Xia, Wenqing
Feng, Yuan
Li, Xiaowei
Zhang, Jian
Feng, Xu
Wang, Cong-Xiao
Cai, Yu
Wang, Jian
Teng, Gao-jun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction.
To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), to examine the resting-state interhemispheric functional connectivity and its relationships with clinical characteristics in chronic tinnitus patients.
Materials and Methods.
Twenty-eight chronic tinnitus patients with normal hearing thresholds and 30 age-, sex-, education-, and hearing threshold-matched healthy controls were included in this study and underwent the resting-state fMRI scanning.
We computed the VMHC to analyze the interhemispheric functional coordination between homotopic points of the brain in both groups.
Results.
Compared to the controls, tinnitus patients showed significantly increased VMHC in the middle temporal gyrus, middle frontal gyrus, and superior occipital gyrus.
In tinnitus patients, a positive correlation was found between tinnitus duration and VMHC of the uncus.
Moreover, correlations between VMHC changes and tinnitus distress were observed in the transverse temporal gyrus, superior temporal pole, precentral gyrus, and calcarine cortex.
Conclusions.
These results show altered interhemispheric functional connectivity linked with specific tinnitus characteristics in chronic tinnitus patients, which may be implicated in the neuropathophysiology of tinnitus.
American Psychological Association (APA)
Chen, Yu-Chen& Xia, Wenqing& Feng, Yuan& Li, Xiaowei& Zhang, Jian& Feng, Xu…[et al.]. 2015. Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055134
Modern Language Association (MLA)
Chen, Yu-Chen…[et al.]. Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055134
American Medical Association (AMA)
Chen, Yu-Chen& Xia, Wenqing& Feng, Yuan& Li, Xiaowei& Zhang, Jian& Feng, Xu…[et al.]. Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055134