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Is the Experience of Thermal Pain Genetics Dependent?
Joint Authors
Dahl, Jørgen B.
Horjales-Araujo, Emilia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It is suggested that genetic variations explain a significant portion of the variability in pain perception; therefore, increased understanding of pain-related genetic influences may identify new targets for therapies and treatments.
The relative contribution of the different genes to the variance in clinical and experimental pain responses remains unknown.
It is suggested that the genetic contributions to pain perception vary across pain modalities.
For example, it has been suggested that more than 60% of the variance in cold pressor responses can be explained by genetic factors; in comparison, only 26% of the variance in heat pain responses is explained by these variations.
Thus, the selection of pain model might markedly influence the magnitude of the association between the pain phenotype and genetic variability.
Thermal pain sensation is complex with multiple molecular and cellular mechanisms operating alone and in combination within the peripheral and central nervous system.
It is thus highly probable that the thermal pain experience is affected by genetic variants in one or more of the pathways involved in the thermal pain signaling.
This review aims to present and discuss some of the genetic variations that have previously been associated with different experimental thermal pain models.
American Psychological Association (APA)
Horjales-Araujo, Emilia& Dahl, Jørgen B.. 2015. Is the Experience of Thermal Pain Genetics Dependent?. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055145
Modern Language Association (MLA)
Horjales-Araujo, Emilia& Dahl, Jørgen B.. Is the Experience of Thermal Pain Genetics Dependent?. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055145
American Medical Association (AMA)
Horjales-Araujo, Emilia& Dahl, Jørgen B.. Is the Experience of Thermal Pain Genetics Dependent?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055145