Identification and Biological Characterization of Leishmania (Viannia) guyanensis Isolated from a Patient with Tegumentary Leishmaniasis in Goiás, a Nonendemic Area for This Species in Brazil
Joint Authors
Pinto, Sebastião Alves
Ribeiro-Dias, Fátima
Pires, Alause da Silva
Borges, Arissa Felipe
Cappellazzo Coelho, Adriano
Dorta, Miriam Leandro
Lino Junior, Ruy de Souza
Pereira, Ledice Inacia de Araújo
Pelli de Oliveira, Milton Adriano
de Matos, Grazzielle Guimarães
Abrahamsohn, Ises A.
Lima, Glória Maria Collet de Araújo
Uliana, Silvia R. B.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of this study was to characterize clinical field isolates of Leishmania spp.
obtained from patients with American Tegumentary Leishmaniasis (ATL) who live in Goiás state, Brazil.
The presumed areas of infection were in Goiás, Tocantins, and Pará states.
Three isolates of parasites were identified as L.
(Viannia) braziliensis and one as L.
(V.) guyanensis.
The in vitro growth profiles were found to be similar for all parasites.
Nevertheless, in C57BL/6 mice, L.
(V.) guyanensis infection was better controlled than L.
(V.) braziliensis.
Yet in C57BL/6 mice deficient in interferon gamma, L.
(V.) guyanensis lesions developed faster than those caused by L.
(V.) braziliensis isolates.
In BALB/c mice, the development of lesions was similar for isolates from both species; however, on the 11th week of infection, amastigotes could not be observed in macrophages from L.
(V.) guyanensis-infected mice.
Thus, L.
(V.) guyanensis can be circulating in Goiás, a state where autochthonous cases of this species had not yet been reported.
Considering the difficulties to differentiate L.
(V.) guyanensis from L.
(V.) braziliensis at the molecular, morphological, and clinical (human and murine models) levels, the presence of L.
(V.) guyanensis infections is possibly underestimated in several regions of Brazil.
American Psychological Association (APA)
Pires, Alause da Silva& Borges, Arissa Felipe& Cappellazzo Coelho, Adriano& Dorta, Miriam Leandro& Lino Junior, Ruy de Souza& Pereira, Ledice Inacia de Araújo…[et al.]. 2015. Identification and Biological Characterization of Leishmania (Viannia) guyanensis Isolated from a Patient with Tegumentary Leishmaniasis in Goiás, a Nonendemic Area for This Species in Brazil. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055150
Modern Language Association (MLA)
Pires, Alause da Silva…[et al.]. Identification and Biological Characterization of Leishmania (Viannia) guyanensis Isolated from a Patient with Tegumentary Leishmaniasis in Goiás, a Nonendemic Area for This Species in Brazil. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055150
American Medical Association (AMA)
Pires, Alause da Silva& Borges, Arissa Felipe& Cappellazzo Coelho, Adriano& Dorta, Miriam Leandro& Lino Junior, Ruy de Souza& Pereira, Ledice Inacia de Araújo…[et al.]. Identification and Biological Characterization of Leishmania (Viannia) guyanensis Isolated from a Patient with Tegumentary Leishmaniasis in Goiás, a Nonendemic Area for This Species in Brazil. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055150