High Body Mass Index Is an Indicator of Maternal Hypothyroidism, Hypothyroxinemia, and Thyroid-Peroxidase Antibody Positivity during Early Pregnancy
Joint Authors
Han, Cheng
Li, Chenyan
Mao, Jinyuan
Wang, Weiwei
Xie, Xiaochen
Zhou, Weiwei
Li, Chenyang
Xu, Bin
Bi, Lihua
Meng, Tao
Du, Jianling
Zhang, Shaowei
Gao, Zhengnan
Zhang, Xiaomei
Yang, Liu
Fan, Chenling
Teng, Weiping
Shan, Zhongyan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Maternal thyroid dysfunction in early pregnancy may increase the risk of adverse pregnancy complications and neurocognitive deficiencies in the developing fetus.
Currently, some researchers demonstrated that body mass index (BMI) is associated with thyroid function in nonpregnant population.
Hence, the American Thyroid Association recommended screening thyroid function in obese pregnant women; however, the evidence for this is weak.
For this purpose, our study investigated the relationship between high BMI and thyroid functions during early pregnancy in Liaoning province, an iodine-sufficient region of China.
Methods.
Serum thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid-peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) concentration, urinary iodine concentration (UIC), and BMI were determined in 6303 pregnant women.
Results.
BMI ≥ 25 kg/m2 may act as an indicator of hypothyroxinemia and TPOAb positivity and BMI ≥ 30 kg/m2 was associated with increases in the odds of hypothyroidism, hypothyroxinemia, and TPOAb positivity.
The prevalence of isolated hypothyroxinemia increased among pregnant women with BMI > 24 kg/m2.
Conclusions.
High BMI during early pregnancy may be an indicator of maternal thyroid dysfunction; for Asian women whose BMI > 24 kg/m2 and who are within 8 weeks of pregnancy, thyroid functions should be assessed especially.
American Psychological Association (APA)
Han, Cheng& Li, Chenyan& Mao, Jinyuan& Wang, Weiwei& Xie, Xiaochen& Zhou, Weiwei…[et al.]. 2015. High Body Mass Index Is an Indicator of Maternal Hypothyroidism, Hypothyroxinemia, and Thyroid-Peroxidase Antibody Positivity during Early Pregnancy. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055155
Modern Language Association (MLA)
Han, Cheng…[et al.]. High Body Mass Index Is an Indicator of Maternal Hypothyroidism, Hypothyroxinemia, and Thyroid-Peroxidase Antibody Positivity during Early Pregnancy. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055155
American Medical Association (AMA)
Han, Cheng& Li, Chenyan& Mao, Jinyuan& Wang, Weiwei& Xie, Xiaochen& Zhou, Weiwei…[et al.]. High Body Mass Index Is an Indicator of Maternal Hypothyroidism, Hypothyroxinemia, and Thyroid-Peroxidase Antibody Positivity during Early Pregnancy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055155