Heart Failure: Advanced Development in Genetics and Epigenetics
Joint Authors
Yang, Jian
Xu, Wei-wei
Hu, Shen-jiang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Heart failure (HF) is a complex pathophysiological syndrome that arises from a primary defect in the ability of the heart to take in and/or eject sufficient blood.
Genetic mutations associated with familial dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy can contribute to the various pathologies of HF.
Therefore, genetic screening could be an approach for guiding individualized therapies and surveillance.
In addition, epigenetic regulation occurs via key mechanisms, including ATP-dependent chromatin remodeling, DNA methylation, histone modification, and RNA-based mechanisms.
MicroRNA is also a hot spot in HF research.
This review gives an overview of genetic mutations associated with cardiomyopathy and the roles of some epigenetic mechanisms in HF.
American Psychological Association (APA)
Yang, Jian& Xu, Wei-wei& Hu, Shen-jiang. 2015. Heart Failure: Advanced Development in Genetics and Epigenetics. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055159
Modern Language Association (MLA)
Yang, Jian…[et al.]. Heart Failure: Advanced Development in Genetics and Epigenetics. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055159
American Medical Association (AMA)
Yang, Jian& Xu, Wei-wei& Hu, Shen-jiang. Heart Failure: Advanced Development in Genetics and Epigenetics. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055159