Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells
Joint Authors
Orzechowski, Arkadiusz
Kania, Elżbieta
Pająk, Beata
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Autophagy is a basic catabolic process, serving as an internal engine during responses to various cellular stresses.
As regards cancer, autophagy may play a tumor suppressive role by preserving cellular integrity during tumor development and by possible contribution to cell death.
However, autophagy may also exert oncogenic effects by promoting tumor cell survival and preventing cell death, for example, upon anticancer treatment.
The major factors influencing autophagy are Ca2+ homeostasis perturbation and starvation.
Several Ca2+ channels like voltage-gated T- and L-type channels, IP3 receptors, or CRAC are involved in autophagy regulation.
Glucose transporters, mainly from GLUT family, which are often upregulated in cancer, are also prominent targets for autophagy induction.
Signals from both Ca2+ perturbations and glucose transport blockage might be integrated at UPR and ER stress activation.
Molecular pathways such as IRE 1-JNK-Bcl-2, PERK-eIF2α-ATF4, or ATF6-XBP 1-ATG are related to autophagy induced through ER stress.
Moreover ER molecular chaperones such as GRP78/BiP and transcription factors like CHOP participate in regulation of ER stress-mediated autophagy.
Autophagy modulation might be promising in anticancer therapies; however, it is a context-dependent matter whether inhibition or activation of autophagy leads to tumor cell death.
American Psychological Association (APA)
Kania, Elżbieta& Pająk, Beata& Orzechowski, Arkadiusz. 2015. Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055160
Modern Language Association (MLA)
Kania, Elżbieta…[et al.]. Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055160
American Medical Association (AMA)
Kania, Elżbieta& Pająk, Beata& Orzechowski, Arkadiusz. Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055160