Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats
Joint Authors
Akhter, Samina
Rahman, Md. Atiar
Aklima, Jannatul
Hasan, Md. Rakibul
Hasan Chowdhury, J. M. Kamirul
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats.
Different fractions of Leea macrophylla (Roxb.) crude extract were subjected to analysis for antioxidative effects.
Rats were randomly divided into four groups as normal control, hepatic control, and reference control (silymarin) group and treatment group.
Evaluations were made for the effects of the fractions on serum enzymes and biochemical parameters of CCl4-induced albino rat.
Histopathological screening was also performed to evaluate the changes of liver tissue before and after treatment.
Different fractions of Leea macrophylla showed very potent 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect, FeCl3 reducing effect, superoxide scavenging effect, and iron chelating effect.
Carbon tetrachloride induction increased the level of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) and other biochemical parameters such as lipid profiles, total protein, and CK-MB.
In contrast, treatment of Leea macrophylla reduced the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activities as well as biochemical parameters activities.
L.
macrophylla partially restored the lipid profiles, total protein, and CK-MB.
Histopathology showed the treated liver towards restoration.
Results evidenced that L.
macrophylla can be prospective source of hepatic management in liver injury.
American Psychological Association (APA)
Akhter, Samina& Rahman, Md. Atiar& Aklima, Jannatul& Hasan, Md. Rakibul& Hasan Chowdhury, J. M. Kamirul. 2015. Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055173
Modern Language Association (MLA)
Akhter, Samina…[et al.]. Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055173
American Medical Association (AMA)
Akhter, Samina& Rahman, Md. Atiar& Aklima, Jannatul& Hasan, Md. Rakibul& Hasan Chowdhury, J. M. Kamirul. Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055173