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Evaluation of the Effectiveness of Piper cubeba Extract in the Amelioration of CCl4-Induced Liver Injuries and Oxidative Damage in the Rodent Model
Joint Authors
Raish, Mohd
Al-Sohaibani, Mohammed
Ahmad, Ajaz
Mothana, Ramzi
al-Said, Mansour
al-Yahya, Mohammed
al-Dosari, Mohammed
Rafatullah, Syed
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Liver diseases still represent a major health burden worldwide.
Moreover, medicinal plants have gained popularity in the treatment of several diseases including liver.
Thus, the present study was to evaluate the effectiveness of Piper cubeba fruits in the amelioration of CCl4-induced liver injuries and oxidative damage in the rodent model.
Methods.
Hepatoprotective activity was assessed using various biochemical parameters like SGOT, SGPT, γ-GGT, ALP, total bilirubin, LDH, and total protein.
Meanwhile, in vivo antioxidant activities as LPO, NP-SH, and CAT were measured in rat liver as well as mRNA expression of cytokines such as TNFα, IL-6, and IL-10 and stress related genes iNOS and HO-1 were determined by RT-PCR.
The extent of liver damage was also analyzed through histopathological observations.
Results.
Treatment with PCEE significantly and dose dependently prevented drug induced increase in serum levels of hepatic enzymes.
Furthermore, PCEE significantly reduced the lipid peroxidation in the liver tissue and restored activities of defense antioxidant enzymes NP-SH and CAT towards normal levels.
The administration of PCEE significantly downregulated the CCl4-induced proinflammatory cytokines TNFα and IL-6 mRNA expression in dose dependent manner, while it upregulated the IL-10 and induced hepatoprotective effect by downregulating mRNA expression of iNOS and HO-1 gene.
American Psychological Association (APA)
al-Said, Mansour& Mothana, Ramzi& Raish, Mohd& Al-Sohaibani, Mohammed& al-Yahya, Mohammed& Ahmad, Ajaz…[et al.]. 2015. Evaluation of the Effectiveness of Piper cubeba Extract in the Amelioration of CCl4-Induced Liver Injuries and Oxidative Damage in the Rodent Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055182
Modern Language Association (MLA)
al-Said, Mansour…[et al.]. Evaluation of the Effectiveness of Piper cubeba Extract in the Amelioration of CCl4-Induced Liver Injuries and Oxidative Damage in the Rodent Model. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055182
American Medical Association (AMA)
al-Said, Mansour& Mothana, Ramzi& Raish, Mohd& Al-Sohaibani, Mohammed& al-Yahya, Mohammed& Ahmad, Ajaz…[et al.]. Evaluation of the Effectiveness of Piper cubeba Extract in the Amelioration of CCl4-Induced Liver Injuries and Oxidative Damage in the Rodent Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055182