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Umbilical Neutrophil Gelatinase-Associated Lipocalin Level as an Early Predictor of Acute Kidney Injury in Neonates with Hypoplastic Left Heart Syndrome
Joint Authors
Więcek, Andrzej
Surmiak, Piotr
Baumert, Małgorzata
Fiala, Małgorzata
Walencka, Zofia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Acute kidney injury (AKI) is a primarily described complication after unbalanced systemic perfusion in neonates with congenital heart defects, including hypoplastic left heart syndrome (HLHS).
The aim of the study was to compare the umbilical NGAL concentrations between neonates born with HLHS and healthy infants, as well as to analyze whether the determination of NGAL level could predict AKI in neonates with prenatally diagnosed HLHS.
Twenty-one neonates with prenatally diagnosed HLHS were enrolled as study group and 30 healthy neonates served as controls.
Perinatal characteristics and postnatal parameters were extracted from the hospital neonatal database.
In umbilical cord blood, we determined plasma NGAL concentrations, acid base balance, and lactate and creatinine levels.
In neonates with HLHS, complications (respiratory insufficiency, circulatory failure, NEC, IVH, and AKI) were recorded until the day of cardiosurgery.
We observed in neonates with HLHS higher umbilical NGAL levels compared to controls.
Among 8 neonates with HLHS and diagnosed AKI stage 1, we observed elevated NGAL levels in comparison to those newborns without AKI.
Umbilical NGAL could predict, with high sensitivity and specificity, AKI development in study neonates.
We suggest that the umbilical blood NGAL concentration may be an early marker to predict AKI in neonates with HLHS.
American Psychological Association (APA)
Surmiak, Piotr& Baumert, Małgorzata& Fiala, Małgorzata& Walencka, Zofia& Więcek, Andrzej. 2015. Umbilical Neutrophil Gelatinase-Associated Lipocalin Level as an Early Predictor of Acute Kidney Injury in Neonates with Hypoplastic Left Heart Syndrome. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055187
Modern Language Association (MLA)
Surmiak, Piotr…[et al.]. Umbilical Neutrophil Gelatinase-Associated Lipocalin Level as an Early Predictor of Acute Kidney Injury in Neonates with Hypoplastic Left Heart Syndrome. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055187
American Medical Association (AMA)
Surmiak, Piotr& Baumert, Małgorzata& Fiala, Małgorzata& Walencka, Zofia& Więcek, Andrzej. Umbilical Neutrophil Gelatinase-Associated Lipocalin Level as an Early Predictor of Acute Kidney Injury in Neonates with Hypoplastic Left Heart Syndrome. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055187