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Biological Effects of Listeriolysin O: Implications for Vaccination
Joint Authors
Hernández-Flores, K. G.
Vivanco-Cid, H.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Listeriolysin O (LLO) is a thiol-activated cholesterol-dependent pore-forming toxin and the major virulence factor of Listeria monocytogenes (LM).
Extensive research in recent years has revealed that LLO exerts a wide array of biological activities, during the infection by LM or by itself as recombinant antigen.
The spectrum of biological activities induced by LLO includes cytotoxicity, apoptosis induction, endoplasmic reticulum stress response, modulation of gene expression, intracellular calcium oscillations, and proinflammatory activity.
In addition, LLO is a highly immunogenic toxin and the major target for innate and adaptive immune responses in different animal models and humans.
Recently, the crystal structure of LLO has been published in detail.
Here, we review the structure-function relationship for this fascinating microbial molecule, highlighting the potential uses of LLO in the fields of biomedicine and biotechnology, particularly in vaccination.
American Psychological Association (APA)
Hernández-Flores, K. G.& Vivanco-Cid, H.. 2015. Biological Effects of Listeriolysin O: Implications for Vaccination. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055188
Modern Language Association (MLA)
Hernández-Flores, K. G.& Vivanco-Cid, H.. Biological Effects of Listeriolysin O: Implications for Vaccination. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055188
American Medical Association (AMA)
Hernández-Flores, K. G.& Vivanco-Cid, H.. Biological Effects of Listeriolysin O: Implications for Vaccination. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055188