miR-125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer
Joint Authors
Wu, Shihua
Liu, Feng
Xie, Liming
Peng, Yaling
Lv, Xiaoyuan
Zhu, Yaping
Zhang, Zhiwei
He, Xiusheng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Understanding the molecular mechanisms underlying gastric cancer progression contributes to the development of novel targeted therapies.
In this study, we found that the expression levels of miR-125b were strongly downregulated in gastric cancer and associated with clinical stage and the presence of lymph node metastases.
Additionally, miR-125b could independently predict OS and DFS in gastric cancer.
We further found that upregulation of miR-125b inhibited the proliferation and metastasis of gastric cancer cells in vitro and in vivo.
miR-125b elicits these responses by directly targeting MCL1 (myeloid cell leukemia 1), which results in a marked reduction in MCL1 expression.
Transfection of miR-125b sensitizes gastric cancer cells to 5-FU-induced apoptosis.
By understanding the function and molecular mechanisms of miR-125b in gastric cancer, we may learn that miR-125b has the therapeutic potential to suppress gastric cancer progression and increase drug sensitivity to gastric cancer.
American Psychological Association (APA)
Wu, Shihua& Liu, Feng& Xie, Liming& Peng, Yaling& Lv, Xiaoyuan& Zhu, Yaping…[et al.]. 2015. miR-125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055207
Modern Language Association (MLA)
Wu, Shihua…[et al.]. miR-125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055207
American Medical Association (AMA)
Wu, Shihua& Liu, Feng& Xie, Liming& Peng, Yaling& Lv, Xiaoyuan& Zhu, Yaping…[et al.]. miR-125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055207