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Parameterization of the Age-Dependent Whole Brain Apparent Diffusion Coefficient Histogram
Joint Authors
Klose, Uwe
Batra, Marion
Nägele, Thomas
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
The distribution of apparent diffusion coefficient (ADC) values in the brain can be used to characterize age effects and pathological changes of the brain tissue.
The aim of this study was the parameterization of the whole brain ADC histogram by an advanced model with influence of age considered.
Methods.
Whole brain ADC histograms were calculated for all data and for seven age groups between 10 and 80 years.
Modeling of the histograms was performed for two parts of the histogram separately: the brain tissue part was modeled by two Gaussian curves, while the remaining part was fitted by the sum of a Gaussian curve, a biexponential decay, and a straight line.
Results.
A consistent fitting of the histograms of all age groups was possible with the proposed model.
Conclusions.
This study confirms the strong dependence of the whole brain ADC histograms on the age of the examined subjects.
The proposed model can be used to characterize changes of the whole brain ADC histogram in certain diseases under consideration of age effects.
American Psychological Association (APA)
Klose, Uwe& Batra, Marion& Nägele, Thomas. 2015. Parameterization of the Age-Dependent Whole Brain Apparent Diffusion Coefficient Histogram. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055232
Modern Language Association (MLA)
Klose, Uwe…[et al.]. Parameterization of the Age-Dependent Whole Brain Apparent Diffusion Coefficient Histogram. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055232
American Medical Association (AMA)
Klose, Uwe& Batra, Marion& Nägele, Thomas. Parameterization of the Age-Dependent Whole Brain Apparent Diffusion Coefficient Histogram. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055232