Utility of MicroRNAs and siRNAs in Cervical Carcinogenesis
Joint Authors
Díaz-González, Sacnite del Mar
Benítez-Boijseauneau, Odelia
Bermúdez-Morales, Victor Hugo
Rodríguez-Dorantes, Mauricio
Pérez-Plasencia, Carlos
Peralta-Zaragoza, Oscar
Gómez-Cerón, Claudia
Deas, Jessica
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
MicroRNAs and siRNAs belong to a family of small noncoding RNAs which bind through partial sequence complementarity to 3′-UTR regions of mRNA from target genes, resulting in the regulation of gene expression.
MicroRNAs have become an attractive target for genetic and pharmacological modulation due to the critical function of their target proteins in several signaling pathways, and their expression profiles have been found to be altered in various cancers.
A promising technology platform for selective silencing of cell and/or viral gene expression using siRNAs is currently in development.
Cervical cancer is the most common cancer in women in the developing world and sexually transmitted infection with HPV is the cause of this malignancy.
Therefore, a cascade of abnormal events is induced during cervical carcinogenesis, including the induction of genomic instability, reprogramming of cellular metabolic pathways, deregulation of cell proliferation, inhibition of apoptotic mechanisms, disruption of cell cycle control mechanisms, and alteration of gene expression.
Thus, in the present review article, we highlight new research on microRNA expression profiles which may be utilized as biomarkers for cervical cancer.
Furthermore, we discuss selective silencing of HPV E6 and E7 with siRNAs which represents a potential gene therapy strategy against cervical cancer.
American Psychological Association (APA)
Díaz-González, Sacnite del Mar& Deas, Jessica& Benítez-Boijseauneau, Odelia& Gómez-Cerón, Claudia& Bermúdez-Morales, Victor Hugo& Rodríguez-Dorantes, Mauricio…[et al.]. 2015. Utility of MicroRNAs and siRNAs in Cervical Carcinogenesis. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055237
Modern Language Association (MLA)
Díaz-González, Sacnite del Mar…[et al.]. Utility of MicroRNAs and siRNAs in Cervical Carcinogenesis. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055237
American Medical Association (AMA)
Díaz-González, Sacnite del Mar& Deas, Jessica& Benítez-Boijseauneau, Odelia& Gómez-Cerón, Claudia& Bermúdez-Morales, Victor Hugo& Rodríguez-Dorantes, Mauricio…[et al.]. Utility of MicroRNAs and siRNAs in Cervical Carcinogenesis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055237