DNA Methylation Levels of Melanoma Risk Genes Are Associated with Clinical Characteristics of Melanoma Patients
Joint Authors
Maria-Engler, Silvya Stuchi
de Araújo, Érica S. S.
Pramio, Dimitrius T.
Kashiwabara, André Y.
Pennacchi, Paula C.
Achatz, Maria I.
Campos, Antonio H. J. F. M.
Duprat, João P.
Rosenberg, Carla
Carraro, Dirce M.
Krepischi, Ana C. V.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In melanoma development, oncogenic process is mediated by genetic and epigenetic mutations, and few studies have so far explored the role of DNA methylation either as predisposition factor or biomarker.
We tested patient samples for germline CDKN2A methylation status and found no evidence of inactivation by promoter hypermethylation.
We have also investigated the association of clinical characteristics of samples with the DNA methylation pattern of twelve genes relevant for melanomagenesis.
Five genes (BAP1, MGMT, MITF, PALB2, and POT1) presented statistical association between blood DNA methylation levels and either CDKN2A-mutation status, number of lesions, or Breslow thickness.
In tumors, five genes (KIT, MGMT, MITF, TERT, and TNF) exhibited methylation levels significantly different between tumor groups including acral compared to nonacral melanomas and matched primary lesions and metastases.
Our data pinpoint that the methylation level of eight melanoma-associated genes could potentially represent markers for this disease both in peripheral blood and in tumor samples.
American Psychological Association (APA)
de Araújo, Érica S. S.& Pramio, Dimitrius T.& Kashiwabara, André Y.& Pennacchi, Paula C.& Maria-Engler, Silvya Stuchi& Achatz, Maria I.…[et al.]. 2015. DNA Methylation Levels of Melanoma Risk Genes Are Associated with Clinical Characteristics of Melanoma Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055243
Modern Language Association (MLA)
de Araújo, Érica S. S.…[et al.]. DNA Methylation Levels of Melanoma Risk Genes Are Associated with Clinical Characteristics of Melanoma Patients. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055243
American Medical Association (AMA)
de Araújo, Érica S. S.& Pramio, Dimitrius T.& Kashiwabara, André Y.& Pennacchi, Paula C.& Maria-Engler, Silvya Stuchi& Achatz, Maria I.…[et al.]. DNA Methylation Levels of Melanoma Risk Genes Are Associated with Clinical Characteristics of Melanoma Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055243