Pulmonary Responses of Sprague-Dawley Rats in Single Inhalation Exposure to Graphene Oxide Nanomaterials
Joint Authors
Yu, Il Je
Lee, Ji Hyun
Ahn, Kang Ho
Lee, Gun Ho
Kim, Tae Gyu
Kim, Jin Kwon
Han, Sung Gu
Shin, Jae Hoon
Hwang, Joo Hwan
Lee, Jong Seong
Kim, Keun Soo
Lee, Heon Sang
Song, Nam Woong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Graphene is receiving increased attention due to its potential widespread applications in future.
However, the health effects of graphene have not yet been well studied.
Therefore, this study examined the pulmonary effects of graphene oxide using male Sprague-Dawley rats and a single 6-hour nose-only inhalation technique.
Following the exposure, the rats were allowed to recover for 1 day, 7 days, or 14 days.
A total of three groups were compared: control (fresh air), low concentration ( 0.46 ± 0.06 mg/m3), and high concentration ( 3.76 ± 0.24 mg/m3).
The exposure to graphene oxide did not induce significant changes in the body weights, organ weights, and food consumption during the 14 days of recovery time.
The microalbumin and lactate dehydrogenase levels in the bronchoalveolar lavage (BAL) fluid were not significantly changed due to the exposure.
Similarly, total cell count, macrophages, polymorphonuclear leukocytes, and lymphocytes were not significantly altered in the BAL fluid.
Plus, the histopathological examination of the rat lungs only showed an uptake of graphene oxide in the alveolar macrophages of the high-concentration group.
Therefore, these results demonstrate that the single inhalation exposure to graphene oxide induce minimal toxic responses in rat lungs at the concentrations and time points used in the present study.
American Psychological Association (APA)
Han, Sung Gu& Kim, Jin Kwon& Shin, Jae Hoon& Hwang, Joo Hwan& Lee, Jong Seong& Kim, Tae Gyu…[et al.]. 2015. Pulmonary Responses of Sprague-Dawley Rats in Single Inhalation Exposure to Graphene Oxide Nanomaterials. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055245
Modern Language Association (MLA)
Han, Sung Gu…[et al.]. Pulmonary Responses of Sprague-Dawley Rats in Single Inhalation Exposure to Graphene Oxide Nanomaterials. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055245
American Medical Association (AMA)
Han, Sung Gu& Kim, Jin Kwon& Shin, Jae Hoon& Hwang, Joo Hwan& Lee, Jong Seong& Kim, Tae Gyu…[et al.]. Pulmonary Responses of Sprague-Dawley Rats in Single Inhalation Exposure to Graphene Oxide Nanomaterials. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055245