Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study
Joint Authors
Sobek, Ondřej
Hajduková, Lenka
Prchalová, Darina
Bílková, Zuzana
Koudelková, Martina
Lukášková, Jiřina
Matuchová, Inka
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
NSE and S100B belong among the so-called structural proteins of the central nervous system (CNS).
Lately, this group of structural proteins has been profusely used as specific biomarkers of CNS tissue damage.
So far, the majority of the research papers have focused predominantly on the concentrations of these proteins in blood in relation to CNS damage of various origins.
Considering the close anatomic and functional relationship between the brain or spinal cord and cerebrospinal fluid (CSF), in case of a CNS injury, a rapid and pronounced increase of the concentrations of structural proteins specifically in CSF takes place.
This study inquires into the physiological concentrations of NSE and S100B proteins in CSF, carried out on a sufficiently large group of 601 patients.
The detected values can be used for determination of a normal reference range in CSF in a clinical laboratory diagnostics.
American Psychological Association (APA)
Hajduková, Lenka& Sobek, Ondřej& Prchalová, Darina& Bílková, Zuzana& Koudelková, Martina& Lukášková, Jiřina…[et al.]. 2015. Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055249
Modern Language Association (MLA)
Hajduková, Lenka…[et al.]. Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055249
American Medical Association (AMA)
Hajduková, Lenka& Sobek, Ondřej& Prchalová, Darina& Bílková, Zuzana& Koudelková, Martina& Lukášková, Jiřina…[et al.]. Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055249