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TOP2A Amplification and Overexpression in Hepatocellular Carcinoma Tissues
Joint Authors
Panvichian, Ravat
Tantiwetrueangdet, Anchalee
Leelaudomlipi, Surasak
Angkathunyakul, Napat
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is the leading cause of cancer death in men worldwide owing to limited insights into pathogenesis and unsatisfactory efficacy of current therapies.
HER2 and TOP2A genes are coamplified in breast and some other cancers.
In this study, we investigated gene aberrations of HER2 and TOP2A and protein expressions of HER2, TOP2A, Ki-67, and p53 in tumor and matched nontumor tissues, as well as their associations with clinicopathological features.
Gene aberrations were evaluated by FISH and protein expressions by IHC.
Neither HER2 overexpression nor HER2 gene amplification was observed in both tumor tissues and matched nontumor tissues.
By contrast, TOP2A overexpression was detected in 72.5% of tumor tissues but not detected in matched nontumor tissues.
However, TOP2A gene amplification was not observed in both tumor and matched nontumor tissues.
TOP2A overexpression was significantly associated with HCC tumor tissues (P < 0.001), hepatitis B surface antigen (HBsAg) in the serum (P = 0.004), and Ki-67 (P = 0.038) but not with age, tumor size, alpha-fetoprotein, TP53, and copy number of TOP2A gene and chromosome 17 centromere.
In conclusion, TOP2A overexpression in HCC was not secondary to gene amplification.
In addition, neither HER2 amplification nor overexpression could be used as prognostic and predictive marker in HCC.
American Psychological Association (APA)
Panvichian, Ravat& Tantiwetrueangdet, Anchalee& Angkathunyakul, Napat& Leelaudomlipi, Surasak. 2015. TOP2A Amplification and Overexpression in Hepatocellular Carcinoma Tissues. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055260
Modern Language Association (MLA)
Panvichian, Ravat…[et al.]. TOP2A Amplification and Overexpression in Hepatocellular Carcinoma Tissues. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055260
American Medical Association (AMA)
Panvichian, Ravat& Tantiwetrueangdet, Anchalee& Angkathunyakul, Napat& Leelaudomlipi, Surasak. TOP2A Amplification and Overexpression in Hepatocellular Carcinoma Tissues. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055260