Short-Term Effects of Verapamil and Diltiazem in the Treatment of No Reflow Phenomenon: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Wang, Lan
Cheng, Zhong
Gu, Ye
Peng, Dingfeng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Currently, there is still a lack of an optimal treatment for no reflow phenomenon (NRP).
We analyzed the efficacy and safety of using nondihydropyridine calcium channel antagonists (NDHP, verapamil/diltiazem) in patients suffering from NRP.
Eight RCTs with 494 participants were eligible for analysis.
The pooling analysis showed that intracoronary verapamil/diltiazem injection significantly decreased the occurrence of the coronary NRP (RR: 0.3, 95% CI: 0.16–0.57; P = 0.0002 ) and reduced corrected thrombolysis in myocardial infarction (TIMI) frame Count (WMD = −9.24, 95% CI −13.91–4.57; P = 0.0001 ) in patients with NRP.
Moreover, verapamil/diltiazem treatment showed superiority in reducing wall motion index (WMI) compared to the control at day 1 (WMD = 0.11, 95% CI: 0.02–0.20; P = 0.02 ) ( P < 0.05 ).
There was also a significantly greater decline at occurrence of the major adverse cardiac events between verapamil/diltiazem and control groups (WMD: 0.4, 95% CI: 0.19–0.84; P = 0.02 ).
However, using verapamil/diltiazem did not provide additional improvement of left ventricular ejection fraction post procedure (at 7 days, WMD, 0.1; 95% CI, −2.43–2.63; P = 0.94 ; at 30 days, WMD, 0.42; 95% CI, −2.09–2.92; P = 0.75 ).
NDHP use is beneficial in attenuating NRP and reducing 6-month MACEs in patients with NRP.
American Psychological Association (APA)
Wang, Lan& Cheng, Zhong& Gu, Ye& Peng, Dingfeng. 2015. Short-Term Effects of Verapamil and Diltiazem in the Treatment of No Reflow Phenomenon: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055262
Modern Language Association (MLA)
Wang, Lan…[et al.]. Short-Term Effects of Verapamil and Diltiazem in the Treatment of No Reflow Phenomenon: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055262
American Medical Association (AMA)
Wang, Lan& Cheng, Zhong& Gu, Ye& Peng, Dingfeng. Short-Term Effects of Verapamil and Diltiazem in the Treatment of No Reflow Phenomenon: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055262