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Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates
Joint Authors
Mayani, Hector
Ortiz-Navarrete, Vianney
Vadillo, Eduardo
Vilchis-Ordoñez, Armando
Reyes-López, Alfonso
Quintela-Nuñez del Prado, Henry Martin
Venegas-Vázquez, Jorge
López-Martínez, Briceida
Pelayo, Rosana
Contreras-Quiroz, Adriana
Dorantes-Acosta, Elisa María
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
B-cell acute lymphoblastic leukemia (B-ALL) is a serious public health problem in the pediatric population worldwide, contributing to 85% of deaths from childhood cancers.
Understanding the biology of the disease is crucial for its clinical management and the development of therapeutic strategies.
In line with that observed in other malignancies, chronic inflammation may contribute to a tumor microenvironment resulting in the damage of normal processes, concomitant to development and maintenance of neoplastic cells.
We report here that hematopoietic cells from bone marrow B-ALL have the ability to produce proinflammatory and growth factors, including TNFα, IL-1β, IL-12, and GM-CSF that stimulate proliferation and differentiation of normal stem and progenitor cells.
Our findings suggest an apparently distinct CD13+CD33+ population of leukemic cells contributing to a proinflammatory microenvironment that may be detrimental to long-term normal hematopoiesis within B-ALL bone marrow.
American Psychological Association (APA)
Vilchis-Ordoñez, Armando& Contreras-Quiroz, Adriana& Vadillo, Eduardo& Dorantes-Acosta, Elisa María& Reyes-López, Alfonso& Quintela-Nuñez del Prado, Henry Martin…[et al.]. 2015. Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055276
Modern Language Association (MLA)
Vilchis-Ordoñez, Armando…[et al.]. Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1055276
American Medical Association (AMA)
Vilchis-Ordoñez, Armando& Contreras-Quiroz, Adriana& Vadillo, Eduardo& Dorantes-Acosta, Elisa María& Reyes-López, Alfonso& Quintela-Nuñez del Prado, Henry Martin…[et al.]. Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055276