The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?
Joint Authors
Arias-Loste, María Teresa
Iruzubieta, Paula
Barbier-Torres, Lucía
Martinez-Chantar, Maria Luz
Crespo, Javier
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Drug-induced liver injury (DILI) is a potentially fatal adverse event and the leading cause of acute liver failure in the US and in the majority of Europe.
The liver can be affected directly, in a dose-dependent manner, or idiosyncratically, independently of the dose, and therefore unpredictably.
Currently, DILI is a diagnosis of exclusion that physicians should suspect in patients with unexplained elevated liver enzymes.
Therefore, new diagnostic and prognostic biomarkers are necessary to achieve an early and reliable diagnosis of DILI and thus improve the prognosis.
Although several DILI biomarkers have been found through analytical and genetic tests and pharmacokinetic approaches, none of them have been able to display enough specificity and sensitivity, so new approaches are needed.
In this sense, metabolomics is a strongly and promising emerging field that, from biofluids collected through minimally invasive procedures, can obtain early biomarkers of toxicity, which may constitute specific indicators of liver damage.
American Psychological Association (APA)
Iruzubieta, Paula& Arias-Loste, María Teresa& Barbier-Torres, Lucía& Martinez-Chantar, Maria Luz& Crespo, Javier. 2015. The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055277
Modern Language Association (MLA)
Iruzubieta, Paula…[et al.]. The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055277
American Medical Association (AMA)
Iruzubieta, Paula& Arias-Loste, María Teresa& Barbier-Torres, Lucía& Martinez-Chantar, Maria Luz& Crespo, Javier. The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055277