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Drift of Scroll Wave Filaments in an Anisotropic Model of the Left Ventricle of the Human Heart
Joint Authors
Pravdin, Sergei
Dierckx, Hans
Markhasin, Vladimir S.
Panfilov, Alexander V.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Scroll waves are three-dimensional vortices which occur in excitable media.
Their formation inthe heart results in the onset of cardiac arrhythmias, and the dynamics of their filaments determinethe arrhythmia type.
Most studies of filament dynamics were performed in domains with simplegeometries and generic description of the anisotropy of cardiac tissue.
Recently, we developed ananalytical model of fibre structure and anatomy of the left ventricle (LV) of the human heart.
Here,we perform a systematic study of the dynamics of scroll wave filaments for the cases of positive andnegative tension in this anatomical model.
We study the various possible shapes of LV and differentdegree of anisotropy of cardiac tissue.
We show that, for positive filament tension, the final positionof scroll wave filament is mainly determined by the thickness of the myocardial wall but, however,anisotropy attracts the filament to the LV apex.
For negative filament tension, the filament buckles,and for most cases, tends to the apex of the heart with no or slight dependency on the thickness ofthe LV.
We discuss the mechanisms of the observed phenomena and their implications for cardiacarrhythmias.
American Psychological Association (APA)
Pravdin, Sergei& Dierckx, Hans& Markhasin, Vladimir S.& Panfilov, Alexander V.. 2015. Drift of Scroll Wave Filaments in an Anisotropic Model of the Left Ventricle of the Human Heart. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055290
Modern Language Association (MLA)
Pravdin, Sergei…[et al.]. Drift of Scroll Wave Filaments in an Anisotropic Model of the Left Ventricle of the Human Heart. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055290
American Medical Association (AMA)
Pravdin, Sergei& Dierckx, Hans& Markhasin, Vladimir S.& Panfilov, Alexander V.. Drift of Scroll Wave Filaments in an Anisotropic Model of the Left Ventricle of the Human Heart. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055290