miR-27 and miR-125 Distinctly Regulate Muscle-Enriched Transcription Factors in Cardiac and Skeletal Myocytes
Joint Authors
Lozano-Velasco, Estefanía
Galiano-Torres, Jennifer
Jodar-Garcia, Alvaro
Aranega, Amelia E.
Franco, Diego
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
MicroRNAs are noncoding RNAs of approximately 22–24 nucleotides which are capable of interacting with the 3′ untranslated region of coding RNAs (mRNAs), leading to mRNA degradation and/or protein translation blockage.
In recent years, differential microRNA expression in distinct cardiac development and disease contexts has been widely reported, yet the role of individual microRNAs in these settings remains largely unknown.
We provide herein evidence of the role of miR-27 and miR-125 regulating distinct muscle-enriched transcription factors.
Overexpression of miR-27 leads to impair expression of Mstn and Myocd in HL1 atrial cardiomyocytes but not in Sol8 skeletal muscle myoblasts, while overexpression of miR-125 resulted in selective upregulation of Mef2d in HL1 atrial cardiomyocytes and downregulation in Sol8 cells.
Taken together our data demonstrate that a single microRNA, that is, miR-27 or miR-125, can selectively upregulate and downregulate discrete number of target mRNAs in a cell-type specific manner.
American Psychological Association (APA)
Lozano-Velasco, Estefanía& Galiano-Torres, Jennifer& Jodar-Garcia, Alvaro& Aranega, Amelia E.& Franco, Diego. 2015. miR-27 and miR-125 Distinctly Regulate Muscle-Enriched Transcription Factors in Cardiac and Skeletal Myocytes. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055295
Modern Language Association (MLA)
Galiano-Torres, Jennifer…[et al.]. miR-27 and miR-125 Distinctly Regulate Muscle-Enriched Transcription Factors in Cardiac and Skeletal Myocytes. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055295
American Medical Association (AMA)
Lozano-Velasco, Estefanía& Galiano-Torres, Jennifer& Jodar-Garcia, Alvaro& Aranega, Amelia E.& Franco, Diego. miR-27 and miR-125 Distinctly Regulate Muscle-Enriched Transcription Factors in Cardiac and Skeletal Myocytes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055295