mTOR Kinase: A Possible Pharmacological Target in the Management of Chronic Pain
Joint Authors
Lisi, Lucia
Aceto, Paola
Navarra, Pierluigi
Dello Russo, Cinzia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chronic pain represents a major public health problem worldwide.
Current pharmacological treatments for chronic pain syndromes, including neuropathic pain, are only partially effective, with significant pain relief achieved in 40–60% of patients.
Recent studies suggest that the mammalian target of rapamycin (mTOR) kinase and downstream effectors may be implicated in the development of chronic inflammatory, neuropathic, and cancer pain.
The expression and activity of mTOR have been detected in peripheral and central regions involved in pain transmission.
mTOR immunoreactivity was found in primary sensory axons, in dorsal root ganglia (DRG), and in dorsal horn neurons.
This kinase is a master regulator of protein synthesis, and it is critically involved in the regulation of several neuronal functions, including the synaptic plasticity that is a major mechanism leading to the development of chronic pain.
Enhanced activation of this pathway is present in different experimental models of chronic pain.
Consistently, pharmacological inhibition of the kinase activity turned out to have significant antinociceptive effects in several experimental models of inflammatory and neuropathic pain.
We will review the main evidence from animal and human studies supporting the hypothesis that mTOR may be a novel pharmacological target for the management of chronic pain.
American Psychological Association (APA)
Lisi, Lucia& Aceto, Paola& Navarra, Pierluigi& Dello Russo, Cinzia. 2015. mTOR Kinase: A Possible Pharmacological Target in the Management of Chronic Pain. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055311
Modern Language Association (MLA)
Lisi, Lucia…[et al.]. mTOR Kinase: A Possible Pharmacological Target in the Management of Chronic Pain. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055311
American Medical Association (AMA)
Lisi, Lucia& Aceto, Paola& Navarra, Pierluigi& Dello Russo, Cinzia. mTOR Kinase: A Possible Pharmacological Target in the Management of Chronic Pain. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055311