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The Construction of Common and Specific Significance Subnetworks of Alzheimer’s Disease from Multiple Brain Regions
Joint Authors
Zhang, Na
Zeng, Weiming
Li, Shasha
Yang, Yang
Kong, Wei
Mou, Xiaoyang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions.
The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insights for the pathogenetic mechanism of AD.
In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions.
Protein-protein interaction (PPI) data were integrated to add molecular biological information to construct the functional modules of six AD brain regions by Heinz algorithm.
Then, the simulated annealing algorithm based on edge weight is applied to predicting and optimizing the maximal scoring networks for common and specific genes, respectively, which can remove the weak interactions and add the prediction of strong interactions to increase the accuracy of the networks.
The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis.
In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis.
American Psychological Association (APA)
Kong, Wei& Mou, Xiaoyang& Zhang, Na& Zeng, Weiming& Li, Shasha& Yang, Yang. 2015. The Construction of Common and Specific Significance Subnetworks of Alzheimer’s Disease from Multiple Brain Regions. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055312
Modern Language Association (MLA)
Kong, Wei…[et al.]. The Construction of Common and Specific Significance Subnetworks of Alzheimer’s Disease from Multiple Brain Regions. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055312
American Medical Association (AMA)
Kong, Wei& Mou, Xiaoyang& Zhang, Na& Zeng, Weiming& Li, Shasha& Yang, Yang. The Construction of Common and Specific Significance Subnetworks of Alzheimer’s Disease from Multiple Brain Regions. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055312