Antidepressant-Like Effect of the Leaves of Pseudospondias microcarpa in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway
Joint Authors
Adongo, Donatus Wewura
Kukuia, Kennedy Kwami Edem
Mante, Priscilla Kolibea
Woode, Eric
Ameyaw, E. O.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Depression continues to be a major global health problem.
Although antidepressants are used for its treatment, efficacy is often inconsistent.
Thus, the search for alternative therapeutic medicines for its treatment is still important.
In this study, the antidepressant-like effect of Pseudospondias microcarpa extract (30–300 mg kg−1, p.o.) was investigated in two predictive models of depression—forced swimming test and tail suspension test in mice.
Additionally, the mechanism(s) of action involved were assessed.
Acute treatment with the extract dose dependently reduced immobility of mice in both models.
The antidepressant-like effect of the extract (100 mg kg−1, p.o.) was blocked by p-chlorophenylalanine and cyproheptadine but not prazosin, propranolol, or yohimbine.
Concomitant administration of d-cycloserine and the extract potentiated the anti-immobility effect.
In contrast, d-serine, a full agonist of glycine/NMDA receptors, abolished the effects.
Anti-immobility effects of PME were prevented by pretreatment of mice with L-arginine (750 mg kg−1, i.p.) and sildenafil (5 mg kg−1, i.p.).
On the contrary, pretreatment of mice with L-NAME (30 mg kg−1, i.p.) or methylene blue (10 mg kg−1, i.p.) potentiated its effects.
The extract produces an antidepressant-like effect in the FST and TST that is dependent on the serotoninergic system, NMDA receptor complex, and the nitric oxide pathway.
American Psychological Association (APA)
Adongo, Donatus Wewura& Kukuia, Kennedy Kwami Edem& Mante, Priscilla Kolibea& Ameyaw, E. O.& Woode, Eric. 2015. Antidepressant-Like Effect of the Leaves of Pseudospondias microcarpa in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055329
Modern Language Association (MLA)
Adongo, Donatus Wewura…[et al.]. Antidepressant-Like Effect of the Leaves of Pseudospondias microcarpa in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1055329
American Medical Association (AMA)
Adongo, Donatus Wewura& Kukuia, Kennedy Kwami Edem& Mante, Priscilla Kolibea& Ameyaw, E. O.& Woode, Eric. Antidepressant-Like Effect of the Leaves of Pseudospondias microcarpa in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055329